InflammaShield ✦ Research & References

Clinical Range: 500–1,500 mg/day of standardized curcumin extract in human trials for arthritis and inflammation. Our 585 mg/day (one serving = 2 capsules) falls within the clinically studied range.

Clinical Range: 125–1,000 mg/day of ginger extract or powder in human OA trials, with the leading rheumatoid arthritis trials using 1,500 mg/day whole ginger powder (≈75 mg active gingerols). Our 585 mg/day of 20% extract sits within the studied extract range and delivers 117 mg/day active gingerols — above the active gingerol dose those RA trials provided. (Trials used whole powder; our extract matches on the active constituent, not the whole matrix.)

Clinical Range: 600–900 mg/day of Boswellia serrata extract standardized to 60–65% total boswellic acids in human trials (meta-analyses of OA trials; Arthritis Foundation guidance runs higher, at 900–1,200 mg/day of 60% extract). Our 600 mg/day is at the clinical floor for this extract type and delivers 390 mg total boswellic acids. Note: AKBA-enriched extracts (30% AKBA) are effective at much lower doses (100–250 mg/day); ours is a 65% total-boswellic-acid extract, dosed to the evidence for that form.

Clinical Range: 500–1,000 mg/day of amla extract in human trials for inflammation, oxidative stress, and lipid management. Our 500 mg/day is at the clinical floor. Honest note: the trials below used specific branded extracts standardized for tannin content; our 10:1 extract is dosed at the same milligram floor, and we verify supplier COAs before making any equivalence claims.

Our decision: Black pepper extract (piperine) was removed from InflammaShield in August 2026. The famous “2,000% absorption” claim traces to a single 1998 study whose measurement method is now known to overstate bioavailability. Newer studies using modern analytical methods have failed to replicate the effect, and piperine inhibits CYP3A4 and P-glycoprotein — the same pathways that handle roughly half of common prescription medications. We don’t put an ingredient in the capsule that we can’t defend.

Role: Curcumin, boswellic acids, and gingerols are fat-soluble — they absorb with fat, not water. Dietary fat in the gut drives micelle formation — the tiny droplets that ferry fat-soluble molecules across the intestinal wall — which is why taking these compounds with food improves their absorption. That’s why this formula includes organic MCT (medium-chain triglyceride) as a fat source, and why we recommend taking InflammaShield with a meal. Honest note: the absorption benefit shown in research comes from taking these compounds with dietary fat in general — we have not run absorption testing on this specific formula.

Why this is here: We publish the research on our ingredients in both directions — including the studies we’d rather not have to discuss. Federal post-market surveillance has linked turmeric/curcumin supplements to rare cases of acute liver injury. Here is the data, the context, and where InflammaShield stands.

Where InflammaShield stands:

• No piperine. The absorption booster present in several implicated products is not in this formula — and never will be (see section 5).
• No “enhanced absorption” nanoparticle or micelle technology. LiverTox attributes most reported cases to high-bioavailability delivery systems. InflammaShield is a standard 95% curcuminoid extract, taken with food.
• A moderate, disclosed dose. 585 mg/day — inside the range used in the clinical trials above, not a megadose.
• Know the warning signs. Unusual fatigue, nausea, poor appetite, dark urine, or yellowing of the skin or eyes: stop any supplement and contact a doctor promptly. Outcomes are best when the product is stopped early.
• Check with your doctor first if you have liver disease, gallbladder or bile-duct problems, take blood thinners or other medications, or are pregnant or nursing.

This section exists because silence is the industry standard, and we don’t want to be standard. None of the above is medical advice; it is a summary of public research.